The Radisson Blu
The Radisson Blu, Alexanderplatz is a business hotel but is also family friendly. There is a large aquarium running up through the centre of the hotel with loads of fish and you can get a room overlooking this which will keep your toddler mesmerized for a little while anyway. Cots are available on request.
The Circus Hotel & Apartments
The Circus Hotel and Apartments are centrally located at Rosenthaler Platz and offer some great services for families. You can pre-order a baby kit, which includes a high chair, baby phone, toys and games. Kids games on the iPad and kids films can be ordered from the Bluray library. All cafe services can be ordered as room service and a Laundry service and in-house washing and drying facilities.are available. There is also parking on the premises.
The Elington Hotel
The Ellington Hotel, Nürnberger Str has family rooms from €185 bed and breakfast including entrance to Berlin Zoo or Sea Life Center.
Another option is to book an apartment through Airbnb. This would allow you more flexibility to prepare bottles and meals.